In chemistry, a disulfide bond is a covalent bond, usually derived by the coupling of two thiol groups. The linkage is also called an SS-bond or disulfide bridge. The overall connectivity is therefore R–S–S–R. The terminology is widely used in biochemistry. In formal terms, the connection is a persulfide, in analogy to its congener, peroxide, but this terminology is obscure and is no longer used.

disilfidebond

disulfide bond

n.

The covalent bond between sulfur atoms that binds two peptide chains or different parts of one peptide chain and is a structuraldeterminant in many protein molecules.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

bond

[bond]

the linkage between atoms or radicals of a chemical compound, or the symbol representing this linkage and indicating the number andattachment of the valencies of an atom in constitutional formulas, represented by a pair of dots or a line between atoms, e.g., H—O—H, H—C≡C—H or H:O:H, H:C:::C:H.
coordinate covalent bond a covalent bond in which one of the bonded atoms furnishes both of the shared electrons.
covalent bond a chemical bond between two atoms or radicals formed by the sharing of a pair (single bond), two pairs (double bond), orthree pairs of electrons (triple bond).
disulfide bond a strong covalent bond, —S—S—, important in linking polypeptide chains in proteins, the linkage arising as a result of theoxidation of the sulfhydryl (SH) groups of two molecules of cysteine.
high-energy phosphate bond an energy-rich phosphate linkage present in adenosine triphosphate (ATP), phosphocreatine, and certainother biological molecules. On hydrolysis at pH 7 it yields about 8000 calories per mole, in contrast to the 3000 calories yielded byphosphate esters. The bond stores energy that is used to drive biochemical processes, such as the synthesis of macromolecules,contraction of muscles, and the production of the electrical potentials for nerve conduction.
high-energy sulfur bond an energy-rich sulfur linkage, the most important of which occurs in the acetyl-CoA molecule, the main sourceof energy in fatty acid biosynthesis.
hydrogen bond a weak, primarily electrostatic, bond between a hydrogen atom bound to a highly electronegative element (such asoxygen or nitrogen) in a given molecule, or part of a molecule, and a second highly electronegative atom in another molecule or in adifferent part of the same molecule.
ionic bond a chemical bond in which electrons are transferred from one atom to another so that one bears a positive and the other anegative charge, the attraction between these opposite charges forming the bond.
peptide bond the —CO—NH— linkage formed between the carboxyl group of one amino acid and the amino group of another; it is anamide linkage joining amino acids to form peptides.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

bond

the linkage between atoms or radicals of a chemical compound, or the symbol representing this linkage and indicating the number andattachment of the valencies of an atom in constitutional formulas, e.g. H−O−H, H−C= C−H and can be represented by a pair of dotsbetween atoms, e.g. H:O:H, H:C:::C:H.

coordinate covalent bond

a covalent bond in which one of the bonded atoms furnishes both of the shared electrons.
covalent bond

a chemical bond between two atoms or radicals formed by the sharing of a pair (single bond), two pairs (double bond) or three pairsof electrons (triple bond).
disulfide bond

a strong covalent bond, −S−S−, important in linking polypeptide chains in proteins, the linkage arising as a result of the oxidation ofthe sulfhydryl (SH) groups of two molecules of cysteine.
high-energy phosphate bond

an energy-rich phosphate linkage present in adenosine triphosphate (ATP), phosphocreatine and certain other biological molecules.On hydrolysis at pH 7 it yields about 8000 calories per mole, in contrast to the 3000 calories yielded by phosphate esters. The bondstores energy that is used to drive biochemical processes, such as the synthesis of macromolecules, contraction of muscles, andthe production of the electrical potentials for nerve conduction.
high-energy sulfur bond

an energy-rich sulfur linkage, the most important of which occurs in the acetyl-CoA molecule, the main source of energy in fattyacid biosynthesis.
human-animal bond

the psychological interdependence between humans and companion animals.
hydrogen bond

a weak, primarily electrostatic, bond between a hydrogen atom bound to a highly electronegative element (such as oxygen ornitrogen) in a given molecule, or part of a molecule, and a second highly electronegative atom in another molecule or in a differentpart of the same molecule.
ionic bond

a chemical bond in which electrons are transferred from one atom to another so that one bears a positive and the other a negativecharge, the attraction between these opposite charges forming the bond.
peptide bond

the −CO−NH− linkage formed between the carboxyl group of one amino acid and the amino group of another; it is an amide linkagejoining amino acids to form peptides.
phosphoanhydride bond

a high energy bond present in ATP.
phosphodiester bond

links between nucleotides in nucleic acids.
Saunders Comprehensive Veterinary Dictionary, 3 ed. © 2007 Elsevier, Inc. All rights reserved

di·sul·fide bond

a single bond between two sulfurs; specifically, the -S-S- link binding two peptide chains (or different parts of one peptide chain); alsooccurs as part of the molecule of the amino acid, cystine, and is important as a structural determinant in many peptide and proteinmolecules, for example, keratin, insulin, and oxytocin. A symmetric disulfide is R-S-S-R; R’-S-S-R is a mixed or asymmetric disulfide.
Farlex Partner Medical Dictionary © Farlex 2012

di·sul·fide bond

(dī-sŭl’fīd bond)

A single bond between two sulfurs; specifically, the -S-S- link binding two peptide chains (or different parts of one peptide chain).
Synonym(s): disulphide bond.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
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